SYNTHESIS OF 3'-DEOXY-3'-(2-PROPYNYL)THYMIDINE AND 3'-CYANOMETHYL-3'-DEOXYTHYMIDINE, ANALOGS OF AZT

被引：61

作者：

FIANDOR, J ^{[1
]}

TAM, SY ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,ROCHE RES CTR,NUTLEY,NJ 07110

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)94577-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient procedure using free radical chemistry for introducing a carbon substituent to the 3′-position of 3′-deoxythymidine is described. An application of this procedure to the synthesis of 3′-deoxy-3′-(2-propynyl)thymidine and 3′-cyanomethyl-3′-deoxythymidine, two close analogs of AZT, is presented. © 1990.

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页码：597 / 600

页数：4

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