SEXUAL DIMORPHISM OF STRESS-RESPONSE AND IMMUNE INFLAMMATORY REACTION - THE CORTICOTROPIN-RELEASING HORMONE PERSPECTIVE

被引：25
作者：
VAMVAKOPOULOS, NV
机构：
[1] Department of Biology-Genetics, University of Thessaly Medical School
来源：
MEDIATORS OF INFLAMMATION | 1995年 / 4卷 / 03期
关键词：
AUTOIMMUNITY; CORTICOTROPIN RELEASING HORMONE; ESTROGENS; GLUCOCORTICOIDS; GLUCOCORTICOID RECEPTOR; GONADAL STEROIDS; HEAT SHOCK PROTEINS; HORMONAL REGULATION OF GENE EXPRESSION; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; IMMUNE INFLAMMATORY REACTION; SEXUAL DIMORPHISM; STRESS RESPONSE;
D O I：
10.1155/S0962935195000275
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
THIS review highlights key aspects of corticotropin releasing hormone (CRH) biology of potential relevance to the sexual dimorphism of the stress response and immune/inflammatory reaction, and introduces two important new concepts based on the regulatory potential of the human (h) CRH gene: (1) a proposed mechanism to account for the tissue-specific antithetical responses of hCRH gene expression to glucocorticoids, that may also explain the frequently observed antithetical effects of chronic glucocorticoid administration in clinical practice and (2) a heuristic diagram to illustrate the proposed modulation of the stress response and immune/inflammatory reaction by steroid hormones, from the perspective of the CRH system.
引用
收藏
页码：163 / 174
页数：12
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