STRUCTURAL-CHANGES OF LIPOPROTEIN LIPIDS BY H-1-NMR

被引：9
|
作者：
ALAKORPELA, M
OJA, J
LOUNILA, J
JOKISAARI, J
SAVOLAINEN, MJ
KESANIEMI, YA
机构：
[1] UNIV OULU,DEPT PHYS SCI,NMR RES GRP,SF-90571 OULU,FINLAND
[2] UNIV KUOPIO,AI VIRTANEN INST MOLEC SCI,NMR RES GRP,SF-70211 KUOPIO,FINLAND
[3] UNIV OULU,DEPT INTERNAL MED,SF-90220 OULU,FINLAND
[4] UNIV OULU,BIOCTR,SF-90220 OULU,FINLAND
来源：
CHEMICAL PHYSICS LETTERS | 1995年 / 242卷 / 1-2期
关键词：
D O I：
10.1016/0009-2614(95)00707-B
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A new procedure for detecting structural changes of lipoprotein lipids is introduced and applied to study native low (LDL) and high density lipoprotein (HDL) particles. The method involves lineshape fitting analyses of specific resonances in proton nuclear magnetic resonance spectra together with numerical derivation of the obtained intensity curves with respect to temperature. In addition to the well-known phase transition of the LDL core cholesterol esters, a novel structural change was revealed in the phospholipid monolayer of both native LDL and HDL particles. The attributes of this phenomenon are discussed.
引用
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页码：95 / 100
页数：6
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