NEW AMPHIPATIC POLYMER LIPID CONJUGATES FORMING LONG-CIRCULATING RETICULOENDOTHELIAL SYSTEM-EVADING LIPOSOMES

被引：292

作者：

WOODLE, MC ^{[1
]}

ENGBERS, CM ^{[1
]}

ZALIPSKY, S ^{[1
]}

机构：

[1] LIPOSOME TECHNOL INC,MENLO PK,CA 94025

来源：

BIOCONJUGATE CHEMISTRY | 1994年 / 5卷 / 06期

关键词：

D O I：

10.1021/bc00030a001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid-conjugates of two amphipatic polymers, poly(2-methyl-2-oxazoline) (PMOZ) and poly(2-ethyl-2-oxazoline) (PEOZ) (degree of polymerization approximate to 50) were synthesized by linking glutarate esters of the polymers to distearoylphosphatidylethanolamine (DSPE) or alternatively by termination of the polymerization process with DSPE. Surface-modified liposomes (90 +/- 5 nm) prepared from either conjugate (5 mol % of total lipid) were injected into rats and followed by blood level and tissue distribution measurements. Both polymers PEOZ and PMOZ were found to convey long circulation and low hepatosplenic uptake to liposomes to the same extent as polyethylene glycol (PEG), the best known material for this purpose. This is the first demonstration of protection from rapid recognition and clearance conveyed by alternative polymers, which is equal to the effect of PEG.

引用

页码：493 / 496

页数：4

共 30 条

[1] THE USE OF GLYCOLIPIDS AND HYDROPHILIC POLYMERS IN AVOIDING RAPID UPTAKE OF LIPOSOMES BY THE MONONUCLEAR PHAGOCYTE SYSTEM [J].