SYNTHESIS OF 3-SUBSTITUTED AND 4-SUBSTITUTED CYCLIC ALPHA-AMINO-ACIDS STRUCTURALLY RELATED TO ACPD

被引：22
|
作者：
ALONSO, F
MICO, I
NAJERA, C
SANSANO, JM
YUS, M
EZQUERRA, J
YRURETAGOYENA, B
GRACIA, I
机构：
[1] UNIV ALICANTE,FAC CIENCIAS,DEPT QUIM ORGAN,E-03080 ALACANT,SPAIN
[2] CTR INVEST LILLY SA,E-28130 VALDEOLMOS,SPAIN
来源：
TETRAHEDRON | 1995年 / 51卷 / 37期
关键词：
D O I：
10.1016/0040-4020(95)00586-W
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of 3-substituted cyclopentanones 12-16, 4-substituted cyclohexanones 23-28 and cycloheptanones 38-41 is described. Substituents in the cycloalkanones are carboxylate, phosphonate or tetrazole groups, separated from the ring by a 0, 1, 2, or 3 carbon atoms chain. These cycloalkanones have been transformed into alpha-amino acids 9-11 by hydrolysis of the corresponding hydantoin derivatives 21, 37 and 62, obtained under Bucherer-Bergs reaction conditions.
引用
收藏
页码：10259 / 10280
页数：22
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