SYNTHESIS OF 3-SUBSTITUTED AND 4-SUBSTITUTED CYCLIC ALPHA-AMINO-ACIDS STRUCTURALLY RELATED TO ACPD

被引：22

作者：

ALONSO, F

MICO, I

NAJERA, C

SANSANO, JM

YUS, M

EZQUERRA, J

YRURETAGOYENA, B

GRACIA, I

机构：

[1] UNIV ALICANTE,FAC CIENCIAS,DEPT QUIM ORGAN,E-03080 ALACANT,SPAIN

[2] CTR INVEST LILLY SA,E-28130 VALDEOLMOS,SPAIN

来源：

TETRAHEDRON | 1995年 / 51卷 / 37期

关键词：

D O I：

10.1016/0040-4020(95)00586-W

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of 3-substituted cyclopentanones 12-16, 4-substituted cyclohexanones 23-28 and cycloheptanones 38-41 is described. Substituents in the cycloalkanones are carboxylate, phosphonate or tetrazole groups, separated from the ring by a 0, 1, 2, or 3 carbon atoms chain. These cycloalkanones have been transformed into alpha-amino acids 9-11 by hydrolysis of the corresponding hydantoin derivatives 21, 37 and 62, obtained under Bucherer-Bergs reaction conditions.

引用

页码：10259 / 10280

页数：22

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