EASY DIRECT STEREOSELECTIVE AND REGIOSELECTIVE FORMATION OF BETA-HYDROXY NITRILES BY REACTION OF 1,2-EPOXIDES WITH POTASSIUM CYANIDE IN THE PRESENCE OF METAL-SALTS

被引：76

作者：

CHINI, M ^{[1
]}

CROTTI, P ^{[1
]}

FAVERO, L ^{[1
]}

MACCHIA, F ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO CHIM BIOORGAN,VIA BONANNO 33,I-56126 PISA,ITALY

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 36期

关键词：

BETA-HYDROXY NITRILES; EPOXIDES OPENING REACTIONS; REGIOSELECTIVITY; CATALYSTS;

D O I：

10.1016/S0040-4039(00)92305-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of beta-hydroxy nitriles by the direct opening of 1,2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described. This new method appears to be competitive with the other methods previously reported.

引用

页码：4775 / 4778

页数：4

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