NMDA RECEPTORS ARE INVOLVED IN SPONTANEOUS BURST FIRING OF DOPAMINERGIC MESENCEPHALIC NEURONS

被引：0
作者：
CHERGUI, K [1 ]
CHARLETY, PJ [1 ]
AKAOKA, H [1 ]
BRUNET, JL [1 ]
SAUNIER, CF [1 ]
BUDA, M [1 ]
SVENSSON, TH [1 ]
CHOUVET, G [1 ]
机构：
[1] KAROLINSKA INST,DEPT PHARMACOL,S-10401 STOCKHOLM 60,SWEDEN
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1991年 / 313卷 / 02期
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D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the rat, somatodendritic application of the NMDA antagonist AP-5, within the Substantia Nigra Zona Compacta and Ventral Tegmental Area, either by micro-iontophoresis or pressure ejection, reduces burst firing of dopamine neurons. Similar local application of the non-NMDA antagonist CNQX does not affect their firing pattern. These results indicate that, in vivo, excitatory amino acid afferents participate through NMDA receptors in the control of the spontaneous burst firing of midbrain dopamine neurons.
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页码：139 / 144
页数：6
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