AMBROXOL INHIBITS INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR PRODUCTION IN HUMAN MONONUCLEAR-CELLS

被引：33

作者：

BIANCHI, M ^{[1
]}

MANTOVANI, A ^{[1
]}

ERROI, A ^{[1
]}

DINARELLO, CA ^{[1
]}

GHEZZI, P ^{[1
]}

机构：

[1] TUFTS UNIV,NEW ENGLAND MED CTR,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111

来源：

AGENTS AND ACTIONS | 1990年 / 31卷 / 3-4期

关键词：

D O I：

10.1007/BF01997619

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity. © 1990 Birkhäuser Verlag.

引用

页码：275 / 279

页数：5

共 17 条

[1] NUCLEOTIDE-SEQUENCE OF HUMAN MONOCYTE INTERLEUKIN-1 PRECURSOR CDNA [J].

AURON, PE ;

WEBB, AC ;

ROSENWASSER, LJ ;

MUCCI, SF ;

RICH, A ;

WOLFF, SM ;

DINARELLO, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (24) :7907-7911

[2] CACHECTIN AND TUMOR-NECROSIS-FACTOR AS 2 SIDES OF THE SAME BIOLOGICAL COIN [J].

BEUTLER, B ;

CERAMI, A .

NATURE, 1986, 320 (6063) :584-588

[3] CONTROL OF CACHECTIN (TUMOR-NECROSIS-FACTOR) SYNTHESIS - MECHANISMS OF ENDOTOXIN RESISTANCE [J].

BEUTLER, B ;

KROCHIN, N ;

MILSARK, IW ;

LUEDKE, C ;

CERAMI, A .

SCIENCE, 1986, 232 (4753) :977-980

[4] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[5] INTERLEUKIN-1 [J].

DINARELLO, CA .

REVIEWS OF INFECTIOUS DISEASES, 1984, 6 (01) :51-95

[6]

DONNER C, 1984, Respiration, V46, P146

[7]

GHEZZI P, 1988, J IMMUNOL, V140, P4238

[8] AMELIORATING EFFECT OF MURINE INTERFERON GAMMA ON BLEOMYCIN-INDUCED LUNG COLLAGEN FIBROSIS IN MICE [J].

GIRI, SN ;

HYDE, DM ;

MARAFINO, BJ .

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 1986, 36 (02) :194-197

[9] DEXAMETHASONE INHIBITION OF INTERLEUKIN-1 BETA-PRODUCTION BY HUMAN-MONOCYTES - POSTTRANSCRIPTIONAL MECHANISMS [J].

KERN, JA ;

LAMB, RJ ;

REED, JC ;

DANIELE, RP ;

NOWELL, PC .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (01) :237-244

[10]

KNUDSEN PJ, 1986, J IMMUNOL, V137, P3189

← 1 2 →