THE GROWTH-HORMONE PROLACTIN GENE FAMILY IN RUMINANT PLACENTAE

被引:0
作者
ANTHONY, RV
LIANG, R
KAYL, EP
PRATT, SL
机构
来源
JOURNAL OF REPRODUCTION AND FERTILITY | 1995年
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Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ruminant placentae produce at least two distinct subclasses of the growth hormone/prolactin gene family, the placental lactogens and prolactin-related proteins. Placental lactogens have been purified from cattle, goat and sheep placentae, and the amino acid sequences of bovine and ovine placental lactogen are known. Bovine and ovine placental lactogens are structurally more similar to prolactin than they are to growth hormone. In addition, six unique mRNAs have been described in cattle that encode prolactin-related proteins that are structurally distinct from ruminant placental lactogens. All characterized ruminant placental lactogens and prolactin-related proteins are products of chorionic binucleate cells, but specific biological functions of these placental hormones have not been elucidated. Ovine placental lactogen may modify maternal and fetal intermediary metabolism to provide energy substrates to the fetus. Bovine placental lactogen has been implicated as a luteotropic agent, and is also capable of stimulating mammogenesis and lactogenesis. No ruminant placental lactogen receptor has been structurally characterized, although they are presumed to be similar to either the growth hormone or prolactin receptor. Available technologies will allow many of the questions regarding the regulation, mechanism of action and function of these placental hormones to be addressed.
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页码:83 / 95
页数:13
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