BONE HEALING AFTER BONE-MARROW STROMAL CELL TRANSPLANTATION TO THE BONE DEFECT

被引：44

作者：

NIEDZWIEDZKI, T

DABROWSKI, Z

MISZTA, H

PAWLIKOWSKI, M

机构：

[1] UNIV MIN & MET KRAKOW, BIOMINERAL LAB, KRAKOW, POLAND

[2] NICHOLAS COPERNICUS MED ACAD, DEPT SURG 3, KRAKOW, POLAND

[3] JAGIELLONIAN UNIV, INST ZOOL, ANIM HAEMATOL & TOXICOL, PL-31007 KRAKOW, POLAND

来源：

BIOMATERIALS | 1993年 / 14卷 / 02期

关键词：

OSTEOGENESIS; CELL TRANSPLANTATION; FRACTURE HEALING;

D O I：

10.1016/0142-9612(93)90221-M

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In experimental studies on rabbits, osteogenic properties of stromal cells were confirmed after in vitro growth for 7 and 14 d. The cell suspension was percutaneously transplanted into a surgically produced bone defect in the rabbit's radius. The bone scar produced was X-rayed, and histologically and mineralogically examined after 10, 20 and 40 d follow-ups. Differences in the bone defect healing process (the healing rate and the type of bone tissue produced) were shown between the experimental and the control foreleg. Within the experimental foreleg, healing was considerably accelerated with compact bone formation on a membranous matrix, whilst in the control foreleg, a coarse, fibrous woven bone on a cartilaginous matrix was dominant.

引用

页码：115 / 121

页数：7

共 32 条

[1]

ASHTON BA, 1980, CLIN ORTHOP RELAT R, P294

[2]

ASHTON BA, 1984, CALCIFIED TISSUE INT, V36, P83, DOI 10.1007/BF02405298

[3] REGENERATING BONE-MARROW PRODUCES A POTENT GROWTH-PROMOTING ACTIVITY TO OSTEOGENIC CELLS [J].