GLUCOSIDASE INHIBITORS FOR TREATMENT OF HIV-1 INFECTION

被引：59

作者：

RATNER, L ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1992年 / 8卷 / 02期

关键词：

D O I：

10.1089/aid.1992.8.165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HIV-1 envelope protein is a glycoprotein composed of 120 kD and 41 kD subunits. It contains 30-38 potential asparagine-linked glycosylation sites which have been shown to play a role in CD4 binding, virus uptake, and cytopathogenicity. Several inhibitors of oligosaccharide attachment or modification have been tested. An agent which inhibits glucosidases, N-butyl deoxynojirimycin was found to inhibit HIV-I and SIVmac infectivity, and is currently in clinical trials.

引用

页码：165 / 173

页数：9

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