MODEL STUDY OF HEPATOCYTE TARGETING POLYMERIC SUPER MOLECULAR ASSEMBLY AS DRUG CARRIER

被引：9

作者：

GOTO, M

KOBAYASHI, A

KOBAYASHI, K

SAITO, K

AKAIKE, T

机构：

[1] NAGOYA UNIV, DEPT AGR, CHIKUSA KU, NAGOYA, AICHI 464, JAPAN

[2] TOKYO INST TECHNOL, FAC BIOSCI & BIOTECHNOL, MIDORI KU, YOKOHAMA, KANAGAWA 227, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 01期

关键词：

D O I：

10.1246/cl.1992.123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The drug binding properties of lactose carrying polystyrene (PVLA), which could be endocytosed into hepatocytes due to its interaction with receptors of asialoglycoprotein, were examined by UV and NMR spectroscopies. The results obtained with a hydrophilic drug model, 8-anilino-naphthalene-1-sulphonate (ANS), and with a hydrophobic drug model, 1,6-diphenyl-hexatriene (DPH), indicated the PVLA can be used as a hepatocyte targeting drug carrier.

引用

页码：123 / 126

页数：4

共 10 条

[1]

AKAIKE T, UNPUB

[2]

ASHWELL G, 1987, ANNU REV BIOCHEM, V262, P17384

[3]

EGGENS I, 1989, J BIOL CHEM, V264, P9476

[4]

GOTO M, UNPUB