Pharmacotherapy of Seizures Associated with Lennox-Gastaut Syndrome

被引:0
|
作者
Borggraefe, Ingo [1 ]
Noachtar, Soheyl [2 ]
机构
[1] Childrens Hosp, Dept Pediat Neurol & Dev Med, Munich, Germany
[2] Univ Munich, Dept Neurol, Epilepsy Ctr, Munich, Germany
关键词
epileptic encephalopathy; slow spike-wave complexes; tonic and atonic seizures; cognitive deteriation;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Lennox-Gastaut syndrome is an epileptic encephalopathy starting in early childhood consisting of the triad of cognitive impairment, multiple seizures types and slow spike-wave complexes in the electroencephalogram. Global developmental delay is usually evident before the onset in patients with symptomatic LGS whereas children with cryptogenic LGS might have a normal history of cognitive development before onset of the seizures. The seizure types most commonly associated with LGS are tonic seizures, myoclonic, dialeptic (absence) and astatic seizures. The seizures usually respond poorly to antiepileptic drugs. Cognitive deterioration occurs even in individuals who developed normally before onset of the encephalopathy. In this review, we will focus on the medical, dietary and surgical treatment of seizures associated with this syndrome. The treatment options for LGS have gained recently by emerging randomized controlled trials of new antiepileptic drugs and the introduction of vagal nerve stimulation.
引用
收藏
页码:15 / 24
页数:10
相关论文
共 50 条
  • [1] For generalized seizures associated with the Lennox-Gastaut syndrome
    Motte, J
    Trevathan, E
    Arvidsson, JFV
    Barrera, MN
    Mullens, EL
    Manasco, P
    Dulac, O
    Mai, J
    Billard, C
    Vallee, L
    Oberarztin, F
    Ried, S
    Christe, W
    Rating, D
    Vigevano, F
    Tassinari, C
    Bernardina, BD
    Majoie, H
    Weber, A
    Laegreid, L
    EegOlofsson, O
    Bermejo, M
    Martinez, A
    Castello, JC
    Serra, MTI
    Kirkham, F
    Noronha, M
    Wallace, S
    Black, A
    Berkovic, S
    Pedespan, J
    Echenne, B
    Pinsard, N
    Parain, D
    Peniello, M
    Carriere, J
    Chauvel, P
    Berquin, P
    Garrel, S
    Schaff, J
    Talvik, T
    Douchowny, M
    Gilman, J
    Pellock, J
    Cheng, R
    Crumrine, P
    Lynch, B
    Hahn, J
    Griesemer, D
    Wannamaker, B
    NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (25): : 1807 - 1812
  • [2] Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome
    Trevathan, E
    Mullens, EL
    Manasco, P
    NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (12): : 851 - 852
  • [3] Management of Seizures in Lennox-Gastaut Syndrome
    Crumrine, Patricia K.
    PEDIATRIC DRUGS, 2011, 13 (02) : 107 - 118
  • [4] Management of Seizures in Lennox-Gastaut Syndrome
    Patricia K. Crumrine
    Pediatric Drugs, 2011, 13 : 107 - 118
  • [5] Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome
    Glauser, T.
    Kluger, G.
    Sachdeo, R.
    Krauss, G.
    Perdomo, C.
    Arroyo, S.
    NEUROLOGY, 2008, 70 (21) : 1950 - 1958
  • [6] Eating seizures in Lennox-Gastaut syndrome
    Lee, IH
    Kwan, SY
    Su, MS
    EUROPEAN NEUROLOGY, 2001, 45 (02) : 123 - 125
  • [7] ELECTROCLINICAL SEIZURES IN LENNOX-GASTAUT SYNDROME
    YAQUB, BA
    EPILEPSIA, 1993, 34 (01) : 120 - 127
  • [9] CINROMIDE IN THE TREATMENT OF SEIZURES IN THE LENNOX-GASTAUT SYNDROME
    LOCKMAN, LA
    ROTHNER, AD
    ERENBERG, G
    WRIGHT, FW
    CLOUTIER, G
    GEIGER, EH
    EPILEPSIA, 1981, 22 (02) : 241 - 241
  • [10] LENNOX-GASTAUT SYNDROME - TREATMENT OF SEIZURES WITH FELBAMATE
    GAROFALO, EA
    OLSON, LD
    SACKELLARES, JC
    KOMARYNSKI, MA
    TORNOW, MA
    TRIPATHI, A
    ANNALS OF NEUROLOGY, 1991, 30 (03) : 492 - 492