IN-VITRO ELUTION OF OFLOXACIN FROM A BIOABSORBABLE POLYMER

被引：29

作者：

NIE, L

NICOLAU, DP

NIGHTINGALE, CH

BROWNER, BD

QUINTILIANI, R

机构：

[1] HARTFORD HOSP,DEPT ORTHOPED SURG,HARTFORD,CT 06102

[2] HARTFORD HOSP,DEPT PHARM,HARTFORD,CT 06102

[3] HARTFORD HOSP,RES OFF,HARTFORD,CT 06102

[4] SHANDONG MED UNIV,AFFILIATED HOSP,DEPT ORTHOPED,SHANDONG 250012,PEOPLES R CHINA

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1995年 / 66卷 / 04期

关键词：

D O I：

10.3109/17453679508995563

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

A drawback with antibiotic-loaded polymethylmethacrylate (PMMA) beads is the second surgical procedure that may be required to remove the beads. We explored alternatives for the local delivery of antimicrobials and studied the release characteristics of ofloxacin (10 mg) when incorporated into either 30 or 50 mg beads of two different molar ratios of a bioabsorbable lactide: glycolide polymer. An elution method was employed over a 60-day period at 37 degrees C. After 60 days, about half of the ofloxacin had been released from the composites containing 50 mg and 30 mg of the 85:15 polymer, whereas nearly all of the ofloxacin had been released from both sizes of the 50:50 polymer composites.

引用

页码：365 / 368

页数：4