SYNTHETIC FKBP12 LIGANDS - DESIGN AND SYNTHESIS OF PYRANOSE REPLACEMENTS

被引：9

作者：

BIRKENSHAW, TN ^{[1
]}

CAFFREY, MV ^{[1
]}

CLADINGBOEL, DE ^{[1
]}

COOPER, ME ^{[1
]}

DONALD, DK ^{[1
]}

FURBER, M ^{[1
]}

HARDERN, DN ^{[1
]}

HARRISON, RP ^{[1
]}

MARRIOTT, DP ^{[1
]}

PERRY, MWD ^{[1
]}

STOCKS, MJ ^{[1
]}

TEAGUE, SJ ^{[1
]}

WITHNALL, WJ ^{[1
]}

机构：

[1] FISONS PLC,DIV PHARMACEUT,LOUGHBOROUGH LE11 0RH,LEICS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)80272-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of FKBP12 ligands were designed and synthesised and their affinity for FKBP12 assessed. In these ligands the pyranose ring of FK506 was replaced by other mole synthetically accessible groups. The preparation of suitable intermediates for the synthesis of ''dual domain'' inhibitors (compounds 6a-c, 15 and 22) is also described.

引用

页码：2501 / 2506

页数：6

共 14 条

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