ROLE OF ADENOSINE IN HETEROSYNAPTIC, POSTTETANIC DEPRESSION IN AREA CA1 OF HIPPOCAMPUS

被引：23
作者：
GROVER, LM
TEYLER, TJ
机构：
[1] Neurobiology Department, N.E. Ohio Universities College of Medicine, Rootstown
来源：
NEUROSCIENCE LETTERS | 1993年 / 154卷 / 1-2期
关键词：
ADENOSINE; DEPRESSION; PRESYNAPTIC; HIPPOCAMPUS; HETEROSYNAPTIC; NEUROMODULATION;
D O I：
10.1016/0304-3940(93)90166-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning stimulation, amounted to a 60-80% reduction of excitatory postsynaptic potentials (EPSPs), and required a period of 3-5 min for recovery. Antagonists of A1 adenosine receptors substantially reduced PTD. Adenosine released into, or formed in, the extracellular space during conditioning stimulation may diffuse within the slice to depress evoked release of glutamate,
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页码：39 / 42
页数：4
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