A NEW CHEMOENZYMATIC ENANTIOSELECTIVE SYNTHESIS OF R-(-)-TOMOXETINE, (R)-FLUOXETINE AND (S)-FLUOXETINE

被引：80

作者：

KUMAR, A

NER, DH

DIKE, SY

机构：

[1] Alchemie Research Centre, Thane, 400 601 Maharashtra, Thane- Belapur Road

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(00)85993-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new chemoenzymatic synthesis of optically pure (R)-Tomoxetine and both the enantiomers of Fluoxetine starting from (S)-ethyl-3-hydroxy-3-phenyl propionate obtained by enzymatic methods, is described.

引用

页码：1901 / 1904

页数：4

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