CARBAPENEM AND PENEM ANTIBIOTICS .5. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2-FUNCTIONALIZED-METHYL 1-METHYLCARBAPENEMS RELATED TO ASPARENOMYCINS

被引：0

作者：

IMUTA, M

UYEO, S

YOSHIDA, T

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 03期

关键词：

BETA-LACTAM ANTIBIOTIC; CARBAPENEM ANTIBIOTIC; 1-ALPHA-METHYL CARBAPENEM ANTIBIOTIC; 1-BETA-METHYL CARBAPENEM ANTIBIOTIC; ASPARENOMYCIN; 2-FUNCTIONALIZED-METHYL CARBAPENEM ANTIBIOTIC; LEWIS ACID MEDIATED ALLYLATION; ANTIBACTERIAL ACTIVITY;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 1-alpha- and/or 1-beta-methylcarbapenems, 2-unsubstituted and 2-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl derivatives having a 1-(hydroxy)methylethylidene or cyclic carbonate side chain at the C-6 position, is described. The in vitro antibacterial activities of these compounds and their corresponding 1-unsubstituted carbapenems are compared.

引用

页码：658 / 662

页数：5

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