DIMORPHISM-ASSOCIATED CHANGES IN PLASMA-MEMBRANE H+-ATPASE ACTIVITY OF CANDIDA-ALBICANS

被引：15
|
作者：
KAUR, S [1 ]
MISHRA, P [1 ]
机构：
[1] JAWAHARLAL NEHRU UNIV,SCH LIFE SCI,NEW DELHI 110067,INDIA
来源：
ARCHIVES OF MICROBIOLOGY | 1991年 / 156卷 / 05期
关键词：
DIMORPHISM; PLASMA MEMBRANE; H+-ATPASE; H+-EFFLUX; CANDIDA-ALBICANS;
D O I：
10.1007/BF00248719
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In situ plasma membrane H+-ATPase activity was monitored during pH-regulated dimorphism of Candida albicans using permeabilized cells. ATPase activity was found to increase in both the bud and germ tube forming populations at 135 min which coincides with the time of evagination. Upon reaching the terminal phenotype the mycelial form exhibited higher H+-ATPase activity as compared to the yeast form. At the time of evagination H+-efflux exhibited an increase. K+ depletion resulted in attenuated ATPase activity and glucose induced H+-efflux. The results demonstrate that ATPase may play a regulatory role in dimorphism of C. albicans and K+ acts as a modulator.
引用
收藏
页码：412 / 415
页数：4
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