Prolonged febrile illness due to CTX-M-15 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infection in Nigeria

被引：4

作者：

Aboderin, Oladipo A. ^{[1
,2
]}

Adefehinti, Olufemi ^{[3
]}

Odetoyin, Babatunde W. ^{[1
]}

Olotu, Amadin A. ^{[2
]}

Okeke, Iruka N. ^{[4
]}

Adeodu, Olugbenga O. ^{[3
,5
]}

机构：

[1] Obafemi Awolowo Univ, Dept Med Microbiol & Parasitol, Ife, Nigeria

[2] Obafemi Awolowo Univ Teaching Hosp Complex, Dept Med Microbiol & Parasitol, Ife, Nigeria

[3] Obafemi Awolowo Univ Teaching Hosp Complex, Dept Paediat, Ife, Nigeria

[4] Haverford Coll, Dept Biol, Haverford, PA 19041 USA

[5] Obafemi Awolowo Univ, Dept Paediat & Child Hlth, Ife, Nigeria

来源：

AFRICAN JOURNAL OF LABORATORY MEDICINE | 2012年 / 1卷 / 01期

关键词：

D O I：

10.4102/ajlm.v1i1.16

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum beta-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.

引用

页数：4

共 14 条

[1] Extended-spectrum β-lactamase enzymes in clinical isolates of Enterobacter species from Lagos, Nigeria
Aibinu, IE
Ohaegbulam, VC
Adenipekun, EA
Ogunsola, FT
Odugbemi, TO
Mee, BJ
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (05) : 2197 - 2200
[2] Effect of D240G substitution in a novel ESBL CTX-M-27
Bonnet, R
Recule, C
Baraduc, R
Chanal, C
Sirot, D
De Champs, C
Sirot, J
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (01) : 29 - 35
[3] The CTX-M β-lactamase pandemic
Canton, Rafael
Coque, Teresa M.
[J]. CURRENT OPINION IN MICROBIOLOGY, 2006, 9 (05) : 466 - 475
[4] TRANSFERABLE RESISTANCE TO CEFOTAXIME, CEFOXITIN, CEFAMANDOLE AND CEFUROXIME IN CLINICAL ISOLATES OF KLEBSIELLA-PNEUMONIAE AND SERRATIA-MARCESCENS
KNOTHE, H
SHAH, P
KRCMERY, V
ANTAL, M
MITSUHASHI, S
[J]. INFECTION, 1983, 11 (06) : 315 - 317
[5] PCR MAPPING OF INTEGRONS REVEALS SEVERAL NOVEL COMBINATIONS OF RESISTANCE GENES
LEVESQUE, C
PICHE, L
LAROSE, C
ROY, PH
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (01) : 185 - 191
[6] Detection of blaCTX-M-15 extended-spectrum β-lactamase genes in Escherichia coli from hospital patients in Nigeria
Olowe, O. Adekunle
Grobbel, Mirjam
Buechter, Britta
Luebke-Becker, Antina
Fruth, A.
Wieler, Lothar H.
[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2010, 35 (02) : 207 - 208
[7] Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux
Perichon, Bruno
Bogaerts, Pierre
Lambert, Thierry
Frangeul, Lionel
Courvalin, Patrice
Galimand, Marc
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (07) : 2581 - 2592
[8] Multiresistant Enterobacteriaceae: new threat of an old problem
Pitout, Johann D. D.
[J]. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2008, 6 (05) : 657 - 669
[9] Extended-spectrum β-lactamase-producing enterobacteriaceae:: an emerging public-health concern
Pitout, Johann D. D.
Laupland, Kevin B.
[J]. LANCET INFECTIOUS DISEASES, 2008, 8 (03) : 159 - 166
[10] Chromosome-encoded ambler class A β-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum β-lactamases
Poirel, L
Kämpfer, P
Nordmann, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (12) : 4038 - 4040

← 1 2 →