SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SC-53228, A LEUKOTRIENE B4 RECEPTOR ANTAGONIST WITH HIGH INTRINSIC POTENCY AND SELECTIVITY

被引：21

作者：

DJURIC, SW

DOCTER, SH

YU, SS

SPANGLER, D

TSAI, BS

ANGLIN, CP

GAGINELLA, TS

KACHUR, JF

KEITH, RH

MAZIASZ, TJ

VILLANIPRICE, D

RAO, TS

WALSH, RE

WIDOMSKI, DL

FRETLAND, DJ

机构：

[1] SEARLE R&D,CHESTERFIELD,MO 63198

[2] SEARLE R&D,DEPT IMMUNOINFLAMMATORY DIS RES,SKOKIE,IL 60077

[3] SEARLE R&D,DEPT DRUG DESIGN,SKOKIE,IL 60077

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80853-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Structure Activity Relationship (SAR) studies leading to the identification of a novel high potency Leukotriene B4 receptor antagonist SC-53228 are delineated. This compound shows excelled pharmacodynamic efficacy in animal models of inflammatory disease.

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页码：811 / 816

页数：6

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