SYNTHESIS OF L-BETA-HYDROXYAMINOACIDS USING SERINE HYDROXYMETHYLTRANSFERASE

被引:54
作者
SAEED, A [1 ]
YOUNG, DW [1 ]
机构
[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND
关键词
AMINO ACID; SYNTHESIS; ENZYME; STEREOSPECIFIC; ALDOL;
D O I
10.1016/S0040-4020(01)88770-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The enzyme serine hydroxymethyltransferase (EC 2.1.2.1) has been used in the synthetic direction with a variety of aldehyde substrates to form carbon-carbon bonds with the creation of two chiral centres. A variety of beta-hydroxyaminoacids has been prepared in reasonable yields but, although L-stereospecificity is observed at the alpha-centre, stereospecificity is not high at the beta-centre when the reaction is conducted on the preparative scale.
引用
收藏
页码:2507 / 2514
页数:8
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