SYNTHESIS OF L-BETA-HYDROXYAMINOACIDS USING SERINE HYDROXYMETHYLTRANSFERASE

被引：54

作者：

SAEED, A ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

TETRAHEDRON | 1992年 / 48卷 / 12期

关键词：

AMINO ACID; SYNTHESIS; ENZYME; STEREOSPECIFIC; ALDOL;

D O I：

10.1016/S0040-4020(01)88770-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enzyme serine hydroxymethyltransferase (EC 2.1.2.1) has been used in the synthetic direction with a variety of aldehyde substrates to form carbon-carbon bonds with the creation of two chiral centres. A variety of beta-hydroxyaminoacids has been prepared in reasonable yields but, although L-stereospecificity is observed at the alpha-centre, stereospecificity is not high at the beta-centre when the reaction is conducted on the preparative scale.

引用

页码：2507 / 2514

页数：8

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