REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 - FUNCTIONALITY OF SUBUNITS OF THE HETERODIMER IN DNA-SYNTHESIS

被引：92

作者：

HOSTOMSKY, Z

HOSTOMSKA, Z

FU, TB

TAYLOR, J

机构：

[1] FOX CHASE CANC INST,7701 BURHOLME AVE,PHILADELPHIA,PA 19111

[2] AGOURON PHARMACEUT INC,SAN DIEGO,CA 92121

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 05期

关键词：

D O I：

10.1128/JVI.66.5.3179-3182.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

From an in vitro analysis of the DNA-synthesizing abilities of certain specifically mutated forms of the heterodimeric reverse transcriptase of human immunodeficiency virus type 1, we can conclude that in a heterodimer, the functionality of p66 is necessary while the functionality of the p51 subunit is not needed. Conversely, p51 is not able to catalyze DNA synthesis when associated with p66, and yet when the p66 protein is absent, p51 can function. These conclusions applied to DNA synthesis on heteropolymeric RNA and DNA templates.

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收藏

页码：3179 / 3182

页数：4

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