AUTOIMMUNITY, MICROBIAL IMMUNITY AND THE IMMUNOLOGICAL HOMUNCULUS

被引：453

作者：

COHEN, IR ^{[1
]}

YOUNG, DB ^{[1
]}

机构：

[1] HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH, MRC, TB & RELATED INFECT UNIT, LONDON W12 0HS, ENGLAND

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 04期

关键词：

D O I：

10.1016/0167-5699(91)90093-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clonal deletion and anergy are believed by many immunologists to be the fundamental mechanisms responsible for self tolerance. Nevertheless, as Irun Cohen and Douglas Young point out, such notions of nonreactivity cannot explain certain key features of immune behaviour: the immunological dominance of microbial antigens that mimic self, the uniformity of autoimmune diseases and the prevalence of natural autoimmunity among the healthy. The theory of the immunological homunculus is presented here as a unifying principle.

引用

页码：105 / 110

页数：6

共 75 条

[1] T-CELL RECEPTORS IN MURINE AUTOIMMUNE-DISEASES [J].

ACHAORBEA, H ;

STEINMAN, L ;

MCDEVITT, HO .

ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 :371-405

[2]

[Anonymous], 1959, CLONAL SELECTION THE, DOI DOI 10.5962/BHL.TITLE.8281

[3] A 75 KD MEROZOITE SURFACE PROTEIN OF PLASMODIUM-FALCIPARUM WHICH IS RELATED TO THE 70 KD HEAT-SHOCK PROTEINS [J].

ARDESHIR, F ;

FLINT, JE ;

RICHMAN, SJ ;

REESE, RT .

EMBO JOURNAL, 1987, 6 (02) :493-499

[4] STUDIES ON NATURAL ANTIBODIES AND AUTOANTIBODIES [J].

AVRAMEAS, S ;

DIGHIERO, G ;

LYMBERI, P ;

GUILBERT, B .

ANNALES D IMMUNOLOGIE, 1983, D134 (01) :103-113

[5] A MAJOR ANTIGEN FROM MYCOBACTERIUM-TUBERCULOSIS WHICH IS HOMOLOGOUS TO THE HEAT-SHOCK PROTEINS GROES FROM ESCHERICHIA-COLI AND THE HTPA GENE-PRODUCT OF COXIELLA-BURNETI [J].

BAIRD, PN ;

HALL, LMC ;

COATES, ARM .

NUCLEIC ACIDS RESEARCH, 1988, 16 (18) :9047-9047

[6] MOLECULAR-CLONING OF A PROTECTIVE ANTIGEN OF SCHISTOSOMES [J].

BALLOUL, JM ;

SONDERMEYER, P ;

DREYER, D ;

CAPRON, M ;

GRZYCH, JM ;

PIERCE, RJ ;

CARVALLO, D ;

LECOCQ, JP ;

CAPRON, A .

NATURE, 1987, 326 (6109) :149-153

[7] A REPETITIVE ANTIGEN OF PLASMODIUM-FALCIPARUM THAT IS HOMOLOGOUS TO HEAT-SHOCK PROTEIN 70 OF DROSOPHILA-MELANOGASTER [J].

BIANCO, AE ;

FAVALORO, JM ;

BURKOT, TR ;

CULVENOR, JG ;

CREWTHER, PE ;

BROWN, GV ;

ANDERS, RF ;

COPPEL, RL ;

KEMP, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (22) :8713-8717

[8] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[9] ALDOLASE ACTIVITY OF A PLASMODIUM-FALCIPARUM PROTEIN WITH PROTECTIVE PROPERTIES [J].

CERTA, U ;

GHERSA, P ;

DOBELI, H ;

MATILE, H ;

KOCHER, HP ;

SHRIVASTAVA, IK ;

SHAW, AR ;

PERRIN, LH .

SCIENCE, 1988, 240 (4855) :1036-1038

[10] NATURAL AUTOANTIBODIES MIGHT PREVENT AUTOIMMUNE-DISEASE [J].

COHEN, IR ;

COOKE, A .

IMMUNOLOGY TODAY, 1986, 7 (12) :363-364

← 1 2 3 4 5 6 7 8 →