COMBINED GA-67-CITRATE AND TC-99(M)-HUMAN IMMUNOGLOBULIN IMAGING IN HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS WITH FEVER OF UNDETERMINED ORIGIN

被引：33

作者：

BUSCOMBE, JR

MILLER, RF

LUI, D

ELL, PJ

机构：

[1] Institute of Nuclear Medicine, University College and Middlesex Schools of Medicine, WIN 8AA, Mortimer Street

[2] Academic Department of Medicine, University College and Middlesex Schools of Medicine, WIN 8AA, Mortimer Street

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1991年 / 12卷 / 07期

关键词：

D O I：

10.1097/00006231-199107000-00003

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Patients infected with the human immunodeficiency virus (HIV) suffer from seriou and life-threatening infections. These patients often present with pyrexia but without localizing signs. Despite its high sensitivity in identifying focal infection Ga-67 citrate scintigraphy lacks specificity; lymphoma and solid tumours may also be imaged. This presents particular problems in HIV-positive patients with pyrexia where the differential diagnosis is often between infection and lymphoma. In an attempt to improve the specificity of radionuclide imaging in these patients a combination of Ga-67 citrate and the new agent Tc-99m-labelled human immunoglobulin (Tc-99m-HIG) was used in 25 patients who were sequentially imaged with the two agents. Fourteen patients had 29 sites of microbiologically confirmed infection; Ga-67 citrate identified 27 sites and Tc-99m-HIG identified 16 sites. Seven of the nine sites visualized with Tc-99m-HIG, but positive with Ga-67 citrate, were intrathoracic. Abnormal concentration of Ga-67 citrate, not due to infection, occurred at eight sites; five lymphoma, one gout, one recent fracture and one patient with prominent bone marrow islands. Tc-99m-HIG showed increased concentration of tracer in only one of the patients with lymphoma. A combination of Ga-67 citrate and Tc-99m-HIG imaging in HIV-positive patients with pyrexia of unknown origin enables a differentiation between infection and lymphoma to be made more readily. The poor sensitivity of Tc-99m-HIG in the chest will limit its sole use in this patient group.

引用

页码：583 / 592

页数：10

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