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Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Sherrington Bldg,Ashton St, Liverpool L69 3GE, Merseyside, England Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Sherrington Bldg,Ashton St, Liverpool L69 3GE, Merseyside, England