A Sensitive Simultaneous Determination of Acetaminophen and Indomethacin at Multi-walled Carbon Nanotubes Modified Glassy Carbon Electrode

被引：0
作者：
Babaei, Ali [1 ,2 ]
Farshbaf, Mojtaba [1 ]
Afrasiabi, Mohammad [3 ]
Dehdashti, Aliyeh [1 ]
机构：
[1] Arak Univ, Dept Chem, POB 38156-8-8349, Arak, Iran
[2] Arak Univ, Res Ctr Nanotechnol, Arak, Iran
[3] Islamic Azad Univ, Young Researchers Club, Shoushtar Branch, Shoushtar, Iran
来源：
ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY | 2012年 / 4卷 / 06期
关键词：
Acetaminophen; Indomethacin; Carbon Nanotube; Modified Glassy Carbon Electrode;
D O I：
暂无
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
A chemically modified electrode is constructed based on multi-walled carbon nanotube modified glassy carbon electrode (MWCNTs/GCE) as a sensor for simultaneous determination of acetaminophen (ACT) and indomethacin (INDO) in phosphate buffer (pH 7) solution. The measurements were carried out using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. DPV measurements showed that the linear relationship between oxidation peak current and concentration of ACT and INDO were in the range of 3 |iM to 400 mu M, and 10 mu M to 330 mu M, respectively. Under optimal conditions the modified electrode exhibited high sensitivity and stability for both ACT and INDO determination, making it a suitable sensor for the simultaneous submicromolar detection of ACT and INDO in solutions. The analytical performance of this sensor has been evaluated for detection of ACT and INDO in human serum, human urine and a pharmaceutical preparation with satisfactory results.
引用
收藏
页码：564 / 578
页数：15
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