Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1H-tetrazol-1-yl)ethyl] amino} azetidin-2-one as potential antibacterial agents

被引：0

作者：

Mohite, P. B. ^{[1
]}

Bhaskar, V. H. ^{[2
]}

机构：

[1] Vinayaka Miss Univ, Salem, Tamil Nadu, India

[2] MP Patel Coll Pharm, Kapadwanj, Gujrat, India

来源：

ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY | 2010年 / 2卷 / 04期

关键词：

tetrazole; azetidinone derivatives; antibacterial activity; antitubercular activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some new 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl1Htetrazol1-yl) ethyl] amino} azetidin-2-one have been synthesized from Schiff bases of 5-phenyltetrazole. The Schiff bases were obtained by condensation 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide with various aromatic aldehydes. Cyclocondensation of Schiff's bases with chloroacetylchloride in the presence of triethylamine results in azetidinone derivatives. The structures of the newly synthesized azatidinones were confirmed by FT-IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds have exhibited significant activity against the bacteria and fungi tested.

引用

页码：347 / 355

页数：9

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