Phosphorylation at endothelial cell-cell junctions: Implications for VE-cadherin function

被引：0
作者：
Timmerman, Ilse [1 ]
Hordijk, Peter L. [1 ]
van Buul, Jaap D. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Mol Cell Biol, Sanquin Res & Landsteiner Lab, Amsterdam, Netherlands
来源：
CELL HEALTH AND CYTOSKELETON | 2010年 / 2卷
关键词：
endothelium; VE-cadherin; junctions; barrier; phosphorylation;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Endothelial cell-cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell-cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.
引用
收藏
页码：23 / 31
页数：9
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