SYNTHESIS, PHYSICOCHEMICAL AND CONFORMATIONAL PROPERTIES OF (3R,4R)-3-(3-CYCLOPROPYL-1,2,4-OXADIAZOL-5-YL)-1-AZABICYCLO[2.2.1]HEPTANE, A NOVEL M(1) SELECTIVE MUSCARINIC PARTIAL AGONIST

被引：11

作者：

BAKER, R

SHOWELL, GA

STREET, LJ

SAUNDERS, J

HOOGSTEEN, K

FREEDMAN, SB

HARGREAVES, RJ

机构：

[1] MERCK SHARP & DOHME LTD,DEPT BIOCHEM,HARLOW CM20 2QR,ESSEX,ENGLAND

[2] MERCK SHARP & DOHME LTD,RAHWAY,NJ 07065

[3] MERCK SHARP & DOHME LTD,DEPT PHARMACOL,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 11期

关键词：

D O I：

10.1039/c39920000817

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cyclopropyloxadiazole derivative described in the title has been shown to be a functionally selective M1 partial agonist with antagonist properties in M2 and M3 muscarinic receptor assays; conformational studies indicate free rotation around the oxadiazole-azanorbornane bond, whilst X-ray studies reveal that the cyclopropyl group is in conjugation with the oxadiazole C=N bond.

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页码：817 / 819

页数：3

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