DIFFERENTIATION OF LEYDIG-CELL PRECURSORS INVITRO - A ROLE FOR ANDROGEN

被引：128
|
作者：
HARDY, MP
KELCE, WR
KLINEFELTER, GR
EWING, LL
机构：
[1] US EPA,HLTH EFFECTS RES LAB,RES TRIANGLE PK,NC 27711
[2] US EPA,NORTHROP SERV INC,RES TRIANGLE PK,NC 27711
来源：
ENDOCRINOLOGY | 1990年 / 127卷 / 01期
关键词：
D O I：
10.1210/endo-127-1-488
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
An enriched fraction of mesenchymal-like cells was isolated from the testes of 21 day old rats. Testosterone production (ng/106 cells · 24 hours) by these cells when cultured in vitro was measured by radioimmunoassay of HPLC-purified extracts of culture medium. In the presence of LH + DHT there was a significant increase in testosterone secretion from 22 ± 10 ng after day 1 of culture to 284 ± 75 ng on day 3. © 1990 by The Endocrine Society.
引用
收藏
页码：488 / 490
页数：3
相关论文
共 50 条
  • [1] ANDROGENIC CAPACITY OF LEYDIG-CELL FIBROBLASTIC PRECURSORS
    CHEMES, H
    GOTTLIEB, S
    PASQUALINI, T
    RIVAROLA, M
    BERGADA, C
    JOURNAL OF ANDROLOGY, 1983, 4 (01): : 56 - 56
  • [2] HORMONAL-CONTROL OF LEYDIG-CELL DIFFERENTIATION
    HARDY, MP
    GELBER, SJ
    ZHOU, ZF
    PENNING, TM
    RICIGLIANO, JW
    GANJAM, VK
    NONNEMAN, D
    EWING, LL
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1991, 637 : 152 - 163
  • [3] HORMONAL-REGULATION OF ANDROGEN PRODUCTION BY THE LEYDIG-CELL
    DUFAU, ML
    WINTERS, CA
    HATTORI, M
    AQUILANO, D
    BARANAO, JLS
    NOZU, K
    BAUKAL, A
    CATT, KJ
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1984, 20 (01): : 161 - 173
  • [4] SERTOLI-CELL SOMATOMEDIN-C - PARACRINE ROLE IN INVITRO LEYDIG-CELL GROWTH AND FUNCTIONAL-DIFFERENTIATION - CLINICAL IMPLICATIONS
    CHATELAIN, P
    PERRARDSAPORI, MH
    RUITTON, A
    BERTRAND, J
    FRANCOIS, R
    SAEZ, J
    CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE, 1987, 10 (04): : A45 - A45
  • [5] EFFECT OF CRYPTORCHIDISM ON TESTICULAR AND LEYDIG-CELL ANDROGEN PRODUCTION IN THE MOUSE
    MURPHY, L
    OSHAUGHNESSY, PJ
    INTERNATIONAL JOURNAL OF ANDROLOGY, 1991, 14 (01): : 66 - 74
  • [6] REGULATION OF LEYDIG-CELL TESTOSTERONE FORMATION FROM PROGESTIN PRECURSORS
    KUHNVELTEN, N
    BUNSE, T
    SCHUMACHER, H
    STAIB, W
    ISRAEL JOURNAL OF MEDICAL SCIENCES, 1981, 17 (08): : 729 - 729
  • [7] MALE PSEUDOHERMAPHRODITISM SECONDARY TO AN ABNORMALITY IN LEYDIG-CELL DIFFERENTIATION
    SCHWARTZ, M
    IMPERATOMCGINLEY, J
    PETERSON, RE
    COOPER, G
    MORRIS, PL
    MACGILLIVRAY, M
    HENSLE, T
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (01): : 123 - 127
  • [8] MODULATION OF LEYDIG-CELL FUNCTIONS BY SERTOLI CELLS - INVITRO STUDIES
    REVENTOS, J
    BENAHMED, M
    TABONE, E
    SAEZ, JM
    COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES, 1983, 296 (02): : 123 - 126
  • [9] ETHANOL, A LEYDIG-CELL TOXIN - EVIDENCE OBTAINED INVIVO AND INVITRO
    VANTHIEL, DH
    GAVALER, JS
    COBB, CF
    SANTUCCI, L
    GRAHAM, TO
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1983, 18 : 317 - 323
  • [10] INVITRO SECRETION OF DEOXYCORTICOSTERONE BY A BENIGN LEYDIG-CELL TUMOR OF THE TESTIS
    KARPF, DB
    YAMASHITA, S
    MELMED, S
    KUDISH, H
    BRAUNSTEIN, GD
    JOURNAL OF UROLOGY, 1986, 136 (01): : 114 - 116
12345