DNH DEOXYRIBONUCLEOHELICATES - SELF ASSEMBLY OF OLIGONUCLEOSIDIC DOUBLE-HELICAL METAL-COMPLEXES

被引:233
作者
KOERT, U
HARDING, MM
LEHN, JM
机构
[1] Laboratoire de Chimie Supramoléculaire, Institut le Bel, Univrsité Louis Pasteur, 67000 Strasbourg, 4, rue Blaise Pascal
关键词
D O I
10.1038/346339a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
NUCLEIC acids, because of their key biological role, are ′ targets for the design of either analogues that may mimic some of their features or of complementary ligands that may selectively bind to and react with them for regulation or reaction. Whereas there has been much work on the latter topic since the elucidation of the double-helical structure of DNA1,2, comparatively little has been done on structural and/or functional models, probably owing to the lack of self-organizing molecular systems. Here we present a class of artificial systems, the nucleohelicates, which are of interest from both points of view because they combine the double-helical structure of the double-stranded metal complexes, the helicates2,3, with the selective interaction features of nucleic-acid bases. These functionalized species allow the study of structural effects on the formation of the double helix and on the binding to other entities, in particular to nucleic acids. © 1990 Nature Publishing Group.
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页码:339 / 342
页数:4
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