RESPONSIVENESS TO ORAL DIAZEPAM IN THE ELDERLY - RELATIONSHIP TO TOTAL AND FREE PLASMA-CONCENTRATIONS

被引:57
作者
SWIFT, CG [1 ]
EWEN, JM [1 ]
CLARKE, P [1 ]
STEVENSON, IH [1 ]
机构
[1] UNIV DUNDEE,NINEWELLS HOSP,DEPT PHARMACOL & THERAPEUT,DUNDEE DD1 9SY,SCOTLAND
关键词
D O I
10.1111/j.1365-2125.1985.tb05040.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:111 / 118
页数:8
相关论文
共 33 条
[1]   DESMETHYLDIAZEPAM KINETICS IN THE ELDERLY AFTER ORAL PRAZEPAM [J].
ALLEN, MD ;
GREENBLATT, DJ ;
HARMATZ, JS ;
SHADER, RI .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 28 (02) :196-202
[2]   SPECIFIC BENZODIAZEPINE RECEPTORS IN RAT-BRAIN CHARACTERIZED BY HIGH-AFFINITY [DIAZEPAM-H-3] BINDING - (AFFINITY BINDING DIAZEPAM ANXIOLYTIC ACTIVITY BRAIN MEMBRANES REGIONAL DISTRIBUTION) [J].
BRAESTRUP, C ;
SQUIRES, RF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3805-3809
[3]   INCREASED SENSITIVITY TO NITRAZEPAM IN OLD-AGE [J].
CASTLEDEN, CM ;
GEORGE, CF ;
MARCER, D ;
HALLETT, C .
BRITISH MEDICAL JOURNAL, 1977, 1 (6052) :10-12
[4]   IMMEDIATE AND RESIDUAL EFFECTS IN MAN OF METABOLITES OF DIAZEPAM [J].
CLARKE, CH ;
NICHOLSON, AN .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 6 (04) :325-331
[5]   DIAZEPAM TOLERANCE - EFFECT OF AGE, REGULAR SEDATION, AND ALCOHOL [J].
COOK, PJ ;
FLANAGAN, R ;
JAMES, IM .
BRITISH MEDICAL JOURNAL, 1984, 289 (6441) :351-353
[6]  
De Silva J A, 1970, Anal Chem, V42, P1725, DOI 10.1021/ac50160a040
[7]   NITRAZEPAM AND ELDERLY [J].
EVANS, JG ;
JARVIS, EH .
BRITISH MEDICAL JOURNAL, 1972, 4 (5838) :487-&
[8]  
GARRATINI S, 1973, BIOL EFFECTS DRUGS R, P211
[9]  
GILES HG, 1978, CAN MED ASSOC J, V118, P513
[10]   DIAZEPAM DISPOSITION DETERMINANTS [J].
GREENBLATT, DJ ;
ALLEN, MD ;
HARMATZ, JS ;
SHADER, RI .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 27 (03) :301-312