3-DIMENSIONAL STRUCTURE AND ANTIGEN-BINDING SPECIFICITY OF ANTIBODIES

被引：19

作者：

TELLO, D ^{[1
]}

SPINELLI, S ^{[1
]}

SOUCHON, H ^{[1
]}

SAUL, FA ^{[1
]}

RIOTTOT, MM ^{[1
]}

MARIUZZA, RA ^{[1
]}

LASCOMBE, MB ^{[1
]}

HOUDUSSE, A ^{[1
]}

EISELE, JL ^{[1
]}

FISCHMANN, T ^{[1
]}

CHITARRA, V ^{[1
]}

BOULOT, G ^{[1
]}

BHAT, TN ^{[1
]}

BENTLEY, GA ^{[1
]}

ALZARI, PM ^{[1
]}

POLJAK, RJ ^{[1
]}

机构：

[1] INST PASTEUR,DEPT IMMUNOL,CNRS,URA 359,25 RUE DR ROUX,F-75724 PARIS 15,FRANCE

来源：

BIOCHIMIE | 1990年 / 72卷 / 08期

关键词：

antigen-antibody; Fab-Fv; idiotope-antiidiotope compplex; lysozyme; monoclonal antibody;

D O I：

10.1016/0300-9084(90)90114-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of specific Fab and Fv fragments and their complexes with antigens (avian lysozymes), haptens, and anti-idiotopic Fabs have been studied by immunochemical and crystallographic techniques. Antigen and antibody interact through closely complementary contacting surfaces, without major conformational changes. An idiotopic determinant of a monoclonal antibody is shown to include parts of most of its complementarity determining regions. The specificity of antigen recognition resides in the close complementarity of the antigen determinant with the antibody combining site. © 1990.

引用

页码：507 / 512

页数：6

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