SYNTHESIS OF NEW 1,2,4-TRIAZOLINES AND 1,3,4-THIADIAZOLINES FROM BITHIOUREAS

被引：16

作者：

ERNST, S

RICHTER, C

HOBERT, A

MARIAM, GG

SCHULZE, K

机构：

[1] University of Leipzig, Institute of Organic Chemistry, Leipzig, D-04103

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 01期

关键词：

D O I：

10.1002/jhet.5570320147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,4-Disubstituted thiosemicarbazides 1 react with acyl isothiocyanates to give bithioureas 2, which by the action of sodium ethanolate cyclize to 1,2,4-triazoline-3-thiones 3 and 5, respectively. Treatment of 2 with methyl iodide yields 1,3,4-thiadiazoline-2-imines 8 isomeric with 3. Compound 8d undergoes a thermal induced DIMROTH rearrangement to give 3d in good yield.

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页码：275 / 281

页数：7

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