THE MECHANISM OF TRANSCRIPTION TERMINATION BY RNA POLYMERASE-I

被引：34
作者：
REEDER, RH
LANG, W
机构：
[1] Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington, 98104
来源：
MOLECULAR MICROBIOLOGY | 1994年 / 12卷 / 01期
关键词：
D O I：
10.1111/j.1365-2958.1994.tb00989.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic ribosomal gene transcription units are bordered at their 3' ends by short DNA sequences which specify site-specific termination by RNA polymerase I (polI). Poll terminators from yeast through to mammals appear to follow similar rules: they contain a site for a sequence-specific DNA-binding protein; they function only in one orientation; 3' ends are formed upstream of the binding site; and 5' flanking sequences influence the position and efficiency of 3' end formation. Recent progress in understanding the mechanism of RNA chain elongation by other polymerases suggests a model for polI termination in which termination is seen as one of the several outcomes possible when a polymerase encounters a pause site.
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页码：11 / 15
页数：5
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