EFFECT OF DEHYDRATION ON THE DISPOSITION KINETICS OF ERYTHROMYCIN IN RABBITS

被引：8
作者：
AHMAD, M [1 ]
NIAZI, SK [1 ]
AHMAD, T [1 ]
MUZAFFAR, NA [1 ]
NAWAZ, M [1 ]
机构：
[1] UNIV AGR FAISALABAD,DEPT PHYSIOL & PHARMACOL,FAISALABAD,PAKISTAN
来源：
BIOPHARMACEUTICS & DRUG DISPOSITION | 1992年 / 13卷 / 02期
关键词：
ERYTHROMYCIN; DEHYDRATION;
D O I：
10.1002/bdd.2510130202
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water-deprived population.
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页码：77 / 82
页数：6
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