SELECTIVE RESISTANCE OF TACHYKININ-RESPONSIVE CHOLINERGIC NEURONS IN THE QUINOLINIC ACID LESIONED NEOSTRIATUM

被引：14

作者：

ARENAS, E ^{[1
]}

PEREZNAVARRO, E ^{[1
]}

ALBERCH, J ^{[1
]}

MARSAL, J ^{[1
]}

机构：

[1] UNIV BARCELONA,HOSP BELLVITGE,FAC MED,DEPT BIOL CELLULAR & ANAT PATOL,BARCELONA 7,SPAIN

来源：

BRAIN RESEARCH | 1993年 / 603卷 / 02期

关键词：

STRIATUM; QUINOLINATE EXCITOTOXICITY; ENDOGENOUS ACETYLCHOLINE RELEASE; TACHYKININ; GLUTAMATE;

D O I：

10.1016/0006-8993(93)91254-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied changes on endogenous acetylcholine (ACh) release evoked by different agents from rat neostriatal slices after quinolinic acid (QA) injections. QA lesions induced a biphasic decrease on ACh release evoked by 1 muM glutamate and 50 mM KCl. ACh release evoked by selective tachykinin agonists was only significantly decreased by 250 nmol QA. These results suggest the presence of different functional cholinergic cell populations, with tachykinin-responsive cholinergic neurons selectively spared.

引用

页码：317 / 320

页数：4

共 31 条

[1] EXCITATORY AMINO-ACIDS RELEASE ENDOGENOUS ACETYLCHOLINE FROM RAT STRIATAL SLICES - REGULATION BY GAMMA-AMINOBUTYRIC-ACID [J].