REQUIREMENT FOR LIPOPOLYSACCHARIDE-RESPONSIVE MACROPHAGES IN GALACTOSAMINE-INDUCED SENSITIZATION TO ENDOTOXIN

被引：322
作者：
FREUDENBERG, MA
KEPPLER, D
GALANOS, C
机构：
[1] MAX PLANCK INST IMMUNBIOL, D-7800 FREIBURG, FED REP GER
[2] UNIV FREIBURG, INST BIOCHEM, D-7800 FREIBURG, FED REP GER
来源：
INFECTION AND IMMUNITY | 1986年 / 51卷 / 03期
关键词：
D O I：
10.1128/IAI.51.3.891-895.1986
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Injection of D-galactosamine sensitizes mice many thousand-fold to the lethal action of endotoxin (lipopolysaccharide [LPS]). Comparable sensitization was practically absent in LPS-resistant C3H/HeJ mice, which after D-galactosamine treatment were about 500,000 times less sensitive to LPS lethality than histocompatible LPS-sensitive C3H/HeN mice. D-Galactosamine induces changes in the hepatocytes of treated animals, such as depletion of UTP and alterations in the pattern of UDP sugars. These early biochemical changes, which are necessary for development of sensitization, were similar in both mouse strains which we examined. High sensitivity to the lethal effects of LPS was achieved in C3H/HeJ mice after D-galactosamine treatment by transfer of C3H/HeN macrophages obtained in culture from bone marrow precursor cells.
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页码：891 / 895
页数：5
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