INDUCTION OF SCES BY SOME PYRROLIZIDINE ALKALOIDS IN V79 CHINESE-HAMSTER CELLS CO-CULTURED WITH CHICK-EMBRYO HEPATOCYTES

被引：21
作者：
BRUGGEMAN, IM
VANDERHOEVEN, JCM
机构：
来源：
MUTATION RESEARCH | 1985年 / 142卷 / 04期
关键词：
D O I：
10.1016/0165-7992(85)90025-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genotoxicity of heliotrine, monocrotaline, seneciphylline and senkirkine was studied with the sister-chromatid exchange [SCE] assay in V79 Chinese hamster cells. Exposure to these pyrrolizidine alkaloids, in the presence of co-cultured primary chick embryo hepatocytes, resulted in a high induction of SCE. Co-cultivation of heliotrine with chick embryo hepatocytes resulted in a much higher response than addition of activated rat-liver homogenate to the test medium.
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页码：209 / 212
页数：4
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