CEREBELLAR TOXICITY FOLLOWING HIGH-DOSE CYTOSINE-ARABINOSIDE

被引：40

作者：

DWORKIN, LA

GOLDMAN, RD

ZIVIN, LS

FUCHS, PC

机构：

[1] ST VINCENT HOSP & MED CTR, DEPT PATHOL, 9205 SW BARNES RD, PORTLAND, OR 97209 USA

[2] ST VINCENT HOSP & MED CTR, DEPT MED, PORTLAND, OR 97209 USA

[3] ST VINCENT HOSP & MED CTR, DEPT NEUROL, PORTLAND, OR 97209 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 1985年 / 3卷 / 05期

关键词：

D O I：

10.1200/JCO.1985.3.5.613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient with acute cerebellar toxicity following systemic high-dose cytosine arabinoside (ara-C) 3 g/m2/12 h for secondary acute nonlymphocytic leukemia is reported. Initial symptoms of ataxia and dysarthria emerged at 30 g/m2 cumulative dose and persisted without improvement over a 10 wk period. Recurrence and worsening of cerebellar symptoms followed further consolidation treatment with high-dose ara-C. Subsequent autopsy showed extensive Purkinje''s cell damage in the lateral cerebellar hemispheres. Persistent severe toxicity can occur at total doses less than those generally recognized.

引用

页码：613 / 616

页数：4

共 9 条

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[9] EFFECT OF DOSE AND SCHEDULE ON PHARMACOKINETICS OF HIGH-DOSE CYTOSINE-ARABINOSIDE IN PLASMA AND CEREBROSPINAL-FLUID [J].

SLEVIN, ML ;

PIALL, EM ;

AHERNE, GW ;

HARVEY, VJ ;

JOHNSTON, A ;

LISTER, TA .

JOURNAL OF CLINICAL ONCOLOGY, 1983, 1 (09) :546-551

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