Genetics in Age-Related Macular Degeneration: Current Research and Implications for Future Treatment

被引：1
作者：
Broadhead, Geoffrey Kenneth [1 ,2 ]
Chang, Andrew [1 ,2 ,3 ]
McCluskey, Peter [2 ,3 ]
机构：
[1] Sydney Retina Clin & Day Surg, Level 13,Pk House,187 Macquarie St, Sydney, NSW 2000, Australia
[2] Univ Sydney, Save Sight Inst, Sydney, NSW, Australia
[3] Sydney Eye Hosp, Sydney, NSW, Australia
来源：
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY | 2012年 / 1卷 / 05期
关键词：
age-related macular degeneration; genetics; pharmacogenetics;
D O I：
10.1097/APO.0b013e31826e1d4a
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Age-related macular degeneration (AMD) remains a leading cause of visual loss in the developed world, and genetic factors are known risks for disease development, as well as affecting response to therapy. Here, we review genetic factors associated with AMD and the influence of genetics on the understanding of AMD pathogenesis. The potential role of genetics in assisting in the management of AMD and future research avenues are also discussed.
引用
收藏
页码：312 / 318
页数：7
相关论文
共 100 条
[1]   Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration [J].
Allikmets, R ;
Shroyer, NF ;
Singh, N ;
Seddon, JM ;
Lewis, RA ;
Bernstein, PS ;
Peiffer, A ;
Zabriskie, NA ;
Li, YX ;
Hutchinson, A ;
Dean, M ;
Lupski, JR ;
Leppert, M .
SCIENCE, 1997, 277 (5333) :1805-1807
[2]  
Anand R, 2000, OPHTHALMOLOGY, V107, P2224
[3]   Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants With Respect to Phenotype in Advanced Age-Related Macular Degeneration [J].
Andreoli, Michael T. ;
Morrison, Margaux A. ;
Kim, Ben J. ;
Chen, Ling ;
Adams, Scott M. ;
Miller, Joan W. ;
Deangelis, Margaret M. ;
Kim, Ivana K. .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2009, 148 (06) :869-874
[4]  
Ayyagari R, 2001, Ophthalmic Genet, V22, P233, DOI 10.1076/opge.22.4.233.2219
[5]   The ERCC6 Gene and Age-Related Macular Degeneration [J].
Baas, Dominique C. ;
Despriet, Dominiek D. ;
Gorgels, Theo G. M. F. ;
Bergeron-Sawitzke, Julie ;
Uitterlinden, Andre G. ;
Hofman, Albert ;
van Duijn, Cornelia M. ;
Merriam, Joanna E. ;
Smith, R. Theodore ;
Barile, Gaetano R. ;
ten Brink, Jacoline B. ;
Vingerling, Johannes R. ;
Klaver, Caroline C. W. ;
Allikmets, Rando ;
Dean, Michael ;
Bergen, Arthur A. B. .
PLOS ONE, 2010, 5 (11)
[6]   Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration [J].
Baird, PN ;
Chu, D ;
Guida, E ;
Vu, HTV ;
Guymer, R .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2004, 138 (04) :665-666
[7]   The ε2 and ε4 alleles of the apolipoprotein gene are associated with age-related macular degeneration [J].
Baird, PN ;
Guida, E ;
Chu, DT ;
Vu, HTV ;
Guymer, RH .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (05) :1311-1315
[8]   Polymorphisms in the Vascular Endothelial Growth Factor Gene and Risk of Age-related Macular Degeneration The Rotterdam Study [J].
Boekhoorn, Sharmila S. ;
Isaacs, Aaron ;
Uitterlinden, Andre G. ;
van Duijn, Cornelia M. ;
Hofman, Albert ;
de Jong, Paulus T. V. M. ;
Vingerling, Johannes R. .
OPHTHALMOLOGY, 2008, 115 (11) :1899-1903
[9]   Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration [J].
Boltz, Agnes ;
Ruiss, Manuel ;
Jonas, Jost B. ;
Tao, Yong ;
Rensch, Florian ;
Weger, Martin ;
Garhoefer, Gerhard ;
Frantal, Sophie ;
El-Shabrawi, Yosuf ;
Schmetterer, Leopold .
OPHTHALMOLOGY, 2012, 119 (08) :1615-1620
[10]   Complement in age-related macular degeneration: a focus on function [J].
Bradley, D. T. ;
Zipfel, P. F. ;
Hughes, A. E. .
EYE, 2011, 25 (06) :683-693
12345678910