Ocular pharmacoscintigraphic and aqueous humoral drug availability of ganciclovir-loaded mucoadhesive nanoparticles in rabbits

被引：25

作者：

Akhter, Sohail ^{[1
]}

Ramazani, Farshad ^{[1
]}

Ahmad, Mohammad Zaki ^{[3
]}

Ahmad, Farhan Jalees ^{[4
]}

Rahman, Ziyaur ^{[5
]}

Bhatnagar, Aseem

Storm, Gert ^{[1
,2
]}

机构：

[1] Univ Utrecht, Dept Pharmaceut Sci, Dept Pharmaceut, Univ Weg 99, NL-3584 CG Utrecht, Netherlands

[2] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Targeted Therapeut, NL-7522 NB Enschede, Netherlands

[3] Najran Univ, Coll Pharm, Dept Pharmaceut, Najran, Saudi Arabia

[4] Jamia Hamdard, Fac Pharm, Dept Pharmaceut, Nanomed Res Lab, New Delhi 110062, India

[5] Texas A&M Hlth Sci Ctr, Irma Lerma Rangel Coll Pharm, Kingsville, TX USA

来源：

EUROPEAN JOURNAL OF NANOMEDICINE | 2013年 / 5卷 / 03期

关键词：

aqueous humor; gamma scintigraphy; Ganciclovir; nanoparticles; ocular pharmacokinetics;

D O I：

10.1515/ejnm-2013-0012

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The present report describes the improved ocular retention and aqueous humoral drug availability of ganciclovir (GCV) when administered via topical instillation of different kind of nanoparticles onto the rabbit eye. GCV was loaded into PLGA nanoparticles, chitosan-coated nanoparticles and chitosan-coated niosomal nanoparticles. All three formulations contained nanoparticles equally round in shape with a mean particle size in the range of 180-200 nm. The ocular corneal retention property was evaluated by gamma scintigraphy, revealing that the clearance was slowest in the case of the chitosan-containing formulations. GCV in chitosan-coated PLGA nanoparticles and chitosan-coated niosomal nanoparticles showed approx. 6-fold higher aqueous humor drug availability as compared to a GCV solution and nearly 2.5-fold higher as compared to the chitosan-lacking GCV-PLGA nanoparticles. The results indicate that the use of a mucoadhesive chitosan coating can improve the ocular residence time and aqueous humoral availability of GCV when administered topically in nanoparticles.

引用

页码：159 / 167

页数：9

共 17 条

[1]

Akhter S., Kushwaha S., Warsi M.H., Anwar M., Ahmad M.Z., Ahmad I., Et al., Development and evaluation of nanosized niosomal nanoparticles for oral delivery of Ganciclovir, Drug Dev Ind Pharm, 38, pp. 84-92, (2012)

[2]

Cheng L., Hostetler K.Y., Lee J., Koh H.J., Beadle J.R., Bessho K., Toyoguchi M., Aldern K., Bovet J.-M., Freeman W.R., Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir, Investigative Ophthalmology and Visual Science, 45, 11, pp. 4138-4144, (2004)

[3]

Shen Y., Tu J., Preparation and ocular pharmacokinetics of ganciclovir liposomes, AAPS Journal, 9, 3, (2007)

[4]

Paolicelli P., De La Fuente M., Sanchez A., Seijo B., Alonso M.J., Chitosan nanoparticles for drug delivery to the eye, Expert Opin Drug Deliv, 6, pp. 239-253, (2009)

[5]

Du Toit L.C., Pillay V., Choonara Y.E., Govender T., Carmichael T., Ocular drug delivery-a look towards nanobioadhesives, Expert Opin Drug Deliv, 8, pp. 71-94, (2011)

[6]

Calderon L., Harris R., Cordoba-Diaz M., Elorza M., Elorza B., Lenoir J., Et al., Nano and microparticulate chitosan-based systems for antiviral topical delivery, Eur J Pharm Sci, 48, pp. 216-222, (2013)

[7]

Pahuja P., Arora S., Pawar P., Ocular drug delivery system: A reference to natural polymers, Expert Opin Drug Deliv, 9, pp. 837-861, (2012)

[8]

Lallemand F., Daull P., Benita S., Buggage R., Garrigue J.S., Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb, J Drug Deliv, 60, pp. 42-44, (2012)

[9]

Aggarwal D., Kaur I.P., Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system, International Journal of Pharmaceutics, 290, 1-2, pp. 155-159, (2005)

[10]

Abdelbary G., El-Gendy N., Niosome-encapsulated gentamicin for ophthalmic controlled delivery, AAPS PharmSciTech, 9, pp. 740-747, (2008)

← 1 2 →