Basal Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

被引：15

作者：

Fujimura, Taku ^{[1
]}

Kakizaki, Aya ^{[1
]}

Kambayashi, Yumi ^{[1
]}

Aiba, Setsuya ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi, Japan

来源：

CASE REPORTS IN DERMATOLOGY | 2012年 / 4卷 / 02期

关键词：

Basal cell carcinoma; Spontaneous regression; Tumor-infiltrating lymphocytes;

D O I：

10.1159/000339621

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Spontaneous regression of basal cell carcinoma (BCC) is rare, and characterized by various tumor-infiltrating lymphocytes (TILs) in the tumor. A previous report suggested that these infiltrated lymphocytes consist of type 1 helper T cells, but no detailed phenotypical analysis of other TILs has been demonstrated yet. In this report, we describe an 84-year-old Japanese patient with spontaneous regression of BCC. In the present case, we investigated the immunohistochemical profiles of TILs, not only focusing on the cytotoxic T cells, but the profiles of immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study sheds light on the immunological mechanisms of tumor rejection in human BCC.

引用

页码：125 / 132

页数：8

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