Basal Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

被引：13
|
作者：
Fujimura, Taku [1 ]
Kakizaki, Aya [1 ]
Kambayashi, Yumi [1 ]
Aiba, Setsuya [1 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi, Japan
来源：
CASE REPORTS IN DERMATOLOGY | 2012年 / 4卷 / 02期
关键词：
Basal cell carcinoma; Spontaneous regression; Tumor-infiltrating lymphocytes;
D O I：
10.1159/000339621
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Spontaneous regression of basal cell carcinoma (BCC) is rare, and characterized by various tumor-infiltrating lymphocytes (TILs) in the tumor. A previous report suggested that these infiltrated lymphocytes consist of type 1 helper T cells, but no detailed phenotypical analysis of other TILs has been demonstrated yet. In this report, we describe an 84-year-old Japanese patient with spontaneous regression of BCC. In the present case, we investigated the immunohistochemical profiles of TILs, not only focusing on the cytotoxic T cells, but the profiles of immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study sheds light on the immunological mechanisms of tumor rejection in human BCC.
引用
收藏
页码：125 / 132
页数：8
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