ADENOVIRUS AND ADENOASSOCIATED VIRUS-MEDIATED GENE-TRANSFER

被引：102
作者：
KREMER, EJ
PERRICAUDET, M
机构：
[1] Lab. de Genetique de Virus Oncogenes, Institut Gustave Roussy, Villejuif
来源：
BRITISH MEDICAL BULLETIN | 1995年 / 51卷 / 01期
关键词：
D O I：
10.1093/oxfordjournals.bmb.a072951
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this review we describe current strategies for adenoviral mediated gene transfer (AMGT) and adeno-associated viral mediated gene transfer (AAVMGT). We consider the structure and molecular biology of adenoviruses and adeno-associated viruses and detail the current advantages and disadvantages of AMGT and AAVMGT. Potential solutions to some of the specific drawbacks to AMGT, including the development of new vectors, addition of gp19k, organoides, and the use of non-human adenoviral vectors, are discussed.
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页码：31 / 44
页数：14
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