KINETICS OF ENANTIOSELECTIVE ESTERIFICATION OF NAPROXEN BY LIPASE IN ORGANIC-SOLVENTS

被引：25
作者：
TSAI, SW
WEI, HJ
机构：
[1] Department of Chemical Engineering, National Cheng Kung University, Tainan
来源：
BIOCATALYSIS | 1994年 / 11卷 / 01期
关键词：
LIPASE; NAPROXEN; ESTERIFICATION; ORGANIC SOLVENT;
D O I：
10.3109/10242429409034375
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The kinetics of stereoselective esterification of racemic Naproxen with trimethylsilyl methanol by Candida cylindracea lipase in organic solvents has been investigated. A Ping-Pong Bi Pi mechanism with competitive inhibition by this alcohol for each enantiomer has been identified. The rate equations were further analyzed in the time-course reaction after considering the effect of enzyme deactivation in the organic mixtures, but not in isooctane. Effects of the hydrophobicity of solvent on the solubility of the racemate, the kinetic parameters and their combinations are also discussed.
引用
收藏
页码：33 / 45
页数：13
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