ASCORBATE AND MALONDIALDEHYDE IN STROKE PATIENTS

被引：51

作者：

SHARPE, PC

MULHOLLAND, C

TRINICK, T

机构：

[1] Department of Clinical Biochemistry, Ulster Hospital, Dundonald, Belfast, BT16, ORH

来源：

IRISH JOURNAL OF MEDICAL SCIENCE | 1994年 / 163卷 / 11期

关键词：

D O I：

10.1007/BF02967089

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is believed that free radical formation and subsequent oxidative damage in the form of lipid peroxidation may be a factor in the cerebral damage secondary to the ischaemia of a cerebrovascular accident (CVA). Total serum ascorbate and malondialdehyde (MDA) were measured in 45 patients with CVA on the day of admission to hospital (Time 0) and 48 hours later (Time 48 hours) and also in 45 age and sex matched controls. There was no statistical difference in total serum ascorbate between the control group (34.2 mumol/1 +/- 3.1, mean +/- SEM) and the CVA patients at Time 0 (37.3 +/- 2.9) but there was a statistically significant decrease at Time 48 hours (22.7 +/- 2.0) (p<0.001) in the CVA patients. With MDA there was no statistical difference between the patients at Time 0 (0.79 mumol/l +/- 0.06) and the control group (0.83 +/- 0.06) but there was a significant increase at Time 48 hours (1.65 +/- 0.08) (p<0.001). These findings are in keeping with possible evidence of free radical damage in CVA.

引用

页码：488 / 491

页数：4

共 30 条

[1]

Oberly L.W., Free radicals and diabetes, Free Radical Biology and Medicine, 5, pp. 113-24, (1988)

[2]

Burrell C.J., Blake D.R., Reactive oxygen metabolites and the human myocardium, Br. Heart J., 61, pp. 4-8, (1989)

[3]

Andrews F.J., Blake D.R., Morris C.J., de Sousa M., Iron and joint inflammation, Iron in Immununity, Cancer and inflammation, pp. 145-75, (1989)

[4]

Demopoulos H.B., Flamm E.S., Seligman M.L., Et al., Molecular pathology of lipids in CNS membranes, Oxygen and Physiological Function, pp. 491-508, (1977)

[5]

Demopoulos H.B., Flamm E.S., Pietronigro D.D., Seligman M.L., The free radical pathology and the microcirculation in the major central nervous system disorders, Acta Physiol. Scand. Suppl., 492, pp. 91-118, (1980)

[6]

Flamm E.S., Demopoulos H.B., Seligman M.L., Poser R.G., Ransohoff J., Free radicals in cerebral ischaemia Stroke, 9, pp. 445-7, (1978)

[7]

Demopoulos H.B., The basis of free radical pathology, Fed. Proc., 32, pp. 1859-1961, (1973)

[8]

Gaudet R.J., Levine L., Transcient cerebral ischaemia and brain prostaglandins, Biochem. Biophys. Res. Commun., 86, pp. 893-901, (1979)

[9]

Yoshida S., Inoh S., Asano T., Et al., Effect of transcient ischaemia on free fatty acids and phospholipids in the gerbil 491 brain. Lipid peroxidation as a possible cause of post-ischaemic injury, J. Neurosurg., 53, pp. 323-331, (1980)

[10]

Cooper A.J.L., Pulsinelli W.A., Duffy T.E., Glutathione and ascorbate during ischaemia and post-ischaemic reperfusion in rat brain, J. Neurochem., 35, pp. 1242-1245, (1980)

← 1 2 3 →