ACTIVATION OF NEOCARZINOSTATIN-CHROMOPHORE BY 4-HYDROXYTHIOPHENOL - INTRAMOLECULAR RADICAL TRAPPING OF BIRADICAL INTERMEDIATE

被引：7

作者：

SUGIYAMA, H

FUJIWARA, T

SAITO, I

机构：

[1] Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)78508-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of neocarzinostatin chromphore (1) with 4-hydroxythiophenol under DNA-cleaving conditions was investigated. It was found that a novel cyclization product (5) is formed as a major product together with a minor amount of normal cyclization product 4b. Tritium was incorporated into 4b and 5 from [H-3]-labeled poly(dA-dT), implying that both processes giving 4b and 5 are actually involved in the DNA cleavage reaction.

引用

页码：8825 / 8828

页数：4

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